Assistant ProfessorDepartment of Emergency Medicine Sites of Practice: Harborview Medical CenterFaculty Information Biography Dr. St. John is a clinician-scientist in Emergency Medicine. He cares for patients in the Emergency Department at Harborview Medical Center, and he performs mechanistic and translational research in the UW Emergency Medicine Research Laboratory and at Bloodworks Research Institute. He strives to use his clinical work and research to inform and advance each other to ultimately improve the outcomes of patients. Dr. St. John’s research is focused on understanding the causes of trauma-induced coagulopathy and finding new hemorrhage-control therapies to improve resuscitation outcomes of trauma patients. He has a particular focus on platelet dysfunction after trauma, and he hopes that by developing a deeper understanding of what causes it, he can develop new diagnostic and therapeutic approaches to this problem. He receives funding from the National Heart, Lung, and Blood Institute and the United States Department of Defense. Education & Training: MDUniversity of Arizona College of Medicine2010 Residency, Emergency Medicine University of Arizona2013 Contact Email: firstname.lastname@example.orgMailing Address: University of Washington Medical CenterMagnuson Health Sciences Building,F Wing, UW Box 3572351705 NE Pacific StreetSeattle, WA 98195 Research & Clinical Interests Research Interests: Trauma Trauma-Induced Coagulopathy Platelet Dysfunction Hemorrhage Control Resuscitation of Shock Active Grants: Title: Understanding Microcirculatory Obstruction in Critical Illness Sponsor: UW Royalty Research Fund (RRF) Grant Dates: 1-year Budget: $40,000 Title: Dysregulation of Platelet-von Willebrand Factor Interaction in Trauma-Induced Coagulopathy Sponsor: NIH K08 Grant Dates: 5-year Budget: $780,000 Title: A second-generation prolonged damage control resuscitation cocktail for polytrauma Dates: 2017 - 2020 Role: Co-investigator PI: Dr. Nathan White FTE: 20% Sponsor: United States Department of Defense, Joint Program Committee 6 / Combat Casualty Care Research Program, Prolonged Field Care Research Award (Award number: W81XWH-16-DMRDP-CCCRP-PFCRADM160100) Total Costs: $1,495,028 Title: Therapeutic limb cooling to prevent amputation in prolonged damage control resuscitation Dates: 2017 - 2020 Role: Co-investigator PI: Dr. Eileen Bulger, Department of Surgery, University of Washington FTE: 5% Sponsor: United States Department of Defense, Joint Program Committee 6 / Combat Casualty Care Research Program, Prolonged Field Care Research Award (Award number: W81XWH-16-DMRDP-CCCRP-PFCRADM160100) Total Costs: $1,500,000 Publications PubMed: PubMed BibliographyMy NCBI: My NCBI BibliographyPublications: See below for recent publications: St. John AE, Wang X, Lim EB, Chien D, Stern SA, White NJ. Effects of rapid wound sealing on survival and blood loss in a swine model of lethal junctional arterial hemorrhage. Journal of Trauma and Acute Care Surgery. 2015 Aug; 79(2): 256-62. [Original work]. Baylis JR, Yeon JH, Thomson MH, Kazerooni A, Wang X, St. John AE, Lim EB, Chien D, Lee A, Zhang JQ, Piret JM, Machan LS, Burke TF, White NJ, Kastrup CJ. Self-propelling particles that transport cargo through flowing blood and halt hemorrhage. Science Advances. 2015 Oct; 1(9): e1500379. [Original work]. White NJ, Mehic E, Wang X, Chien D, Lim E, St. John AE, Stern SA, Mourad PD, Rieger M, Fries D, Martinowitz U. Rediscovering the wound haematoma as a site of haemostasis during major arterial haemorrhage. Journal of Thrombosis and Haemostasis. 2015 Dec; 13(12): 2202-9. [Original work]. White N, Wang Y, Fu X, Cardenas JC, Martin EJ, Brophy DF, Wade CE, Wang X, St. John AE, Lim EB, Stern SA, Ward KR, López JA, Chung D. Post-translational oxidative modification of fibrinogen is associated with coagulopathy after traumatic injury. Free Radical Biology and Medicine. 2016 Apr; S0891-5849(16)30041-7. [Original work]. Baylis JR (co-first author), St. John AE (co-first author), Wang X, Lim EB, Statz ML, Chien D, Simonson E, Stern SA, Liggins RT, White NJ, Kastrup CJ. Self-propelled dressing containing thrombin and tranexamic acid improve short-term survival in a swine model of lethal junctional hemorrhage. Shock. 2016 Sep; 46(3 Suppl 1): 123-8. [Original work].