Our University of Washington, Department of Emergency Medicine faculty value high-quality research and are persistently exploring issues rooted in Emergency Medicine, as well as those that intersect it.

Below is a roundup of research being conducted by and with our faculty for the month of January.

Andrew Latimer is the PI on a project titled Clinical Evaluation of Compensatory Reserve Index (CRI) in the Prehospital Setting. The CRI uses a computer algorithm to measure small alterations in the photoplethysmogram (PPG) waveform recorded by a pulse oximetry probe with the goal to detect intravascular volume loss. The CRI algorithm is designed to estimate an individual’s proportion of total tolerable volume loss. CRI values range from 0 to 1 and reflect a proportion of physiologic reserve remaining before hemodynamic decompensation.

This is a prospective observational cohort study attempting to measure CRI values for traumatically injured patients transported by Seattle and King County Medic One Intensive Care Paramedics as well as patients transported directly from the field by Airlift Northwest helicopters to Harborview Medical Center.

The study aims to quantify changes in CRI values from the arrival of the prehospital care team at the patient through field interventions and transfer of care in the emergency department (ED) up until hospital admission for patients with a traumatic mechanism of injury transported to a Level 1 Trauma Center. By collecting this information, the investigators aim to:  

  1. Determine if there is an association between prehospital CRI values and a hospital diagnosis of hemorrhagic shock. 
  2. Determine if prehospital CRI is more predictive of hemorrhagic shock in the ED when compared to other prehospital vital signs. 
  3. Quantify changes in trauma patient CRI values during and following fluid and blood product resuscitation in the prehospital and hospital settings. 
  4. Develop hypotheses that can inform subsequent randomized controlled trial(s) to evaluate CRI’s ability to improve trauma patient clinical outcomes.

Drs. Graham Nichol and Kelli O'Laughlin are PI and Site PI, respectively, on a project titled Innovative Support for Patients with SARSCOV2 Infections (INSPIRE) Registry. This CDC funded project aims to address the lack of empirical data that has limited our understanding of the COVID-19 pandemic and the role of age and other factors in prognosis. The objective of the INSPIRE Study is to rapidly generate knowledge around long-term implications of COVID-19.

This will be done in partnership with Hugo Health, a digital health platform, that will enable the investigators to collect and analyze real-time data, and feedback the information to participants. The investigators will be recruiting individuals who have recently tested for COVID-19 and use their self-reported health information to assess their physical and mental health over an 18-month follow-up period. They will also capture data from the patient's electronic health record to help them understand the long-term sequala of COVID-19 and how these differ based on participant characteristics.

Drs. Ross Kessler, Adeyinka Adedipe, and Kennedy Hall are Co-Investigators on a project titled Lung Ultrasound Sensor for Monitoring Pulmonary Edema. For this study, led by Dr. Tatiana Khokhlova in the Division of Gastroenterology, the research team, including members from Applied Physics' Center for Industrial and Medical Ultrasound, seek to develop a low cost, disposable, automated, continuous, non-imaging lung ultrasound sensor (LUSS) which will aid in diagnosis, triage, and continuous monitoring of patients with lung disease and acute respiratory health concerns such as ARDS. The research proposal is a response to the ongoing need for triage and care of COVID-19 patients and seeks to use innovative technology to reduce the incidence and severity of lung injury secondary to the novel coronavirus.