Dr. White, UW collaborators receive funding for hemorrhagic shock study

Dr. Nathan White and several UW collaborators received new funding for a pilot grant sponsored by the University of Washington 3Rs (Replacement, Reduction, & Refinement).

The grant, titled, 'Microphysiological Systems for Replicating Hemorrhagic Shock: A 3R’s Approach' will look to optimize microphysiological systems (MPS) to faithfully mimic the conditions of hemorrhagic shock.

MPS Perfusion pressure and oxygenation thresholds that align with their current understanding of hemorrhagic shock will be reproduced using vascular MPS and validated for organ injury in humanized kidney proximal tubule MPS. 

Aims: This project aims to improve how we study trauma-related injuries by simulating microvessel and kidney conditions in hemorrhagic shock. By using advanced microphysiological systems, we're working towards more ethical and scientifically robust alternatives to animal models. The outcomes could enhance our understanding of trauma and reduce the need for animal testing, aligning with modern ethical standards in research.

Dr. White, alongside Dr. Ying Zheng of the UW Department of Bioengineering and Center of Cardiovascular Biology will serve as the Principal Investigators. Dr. Cathy Yeung of the UW Department of Pharmacy and an investigator in the Kidney Research Institute will serve as the co-investigator.